| abstract |
Compound of Formula 1 isn n n [Formula 1]n n n Cyclo [NX 1 -R 1 -CO-NX 2 -R 2 -CO-NX 3 -R 3 -CO-NX 4 -R 4 -CO-NX 5 -R 5 -CO],n n n Wherein at least one x-fluoroalkylated amino acid is presentn n n It is an inhibitor of integrins, in particular those belonging to the α v β 3 and α v β 5 families and is therefore particularly useful as a medicament for the treatment of diseases associated with abnormal angiogenesis such as retinopathy, acute renal failure, osteoporosis and cancer metastasis. The compounds described herein are also useful as diagnostic reagents, if properly labeled, particularly for the detection and localization of small tumor masses and arterial blockages. |