http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050024318-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D499-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07B61-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D499-00 |
| filingDate | 2002-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20050024318-A |
| titleOfInvention | Process for preparation of penam derivatives from cepham derivatives |
| abstract | The present invention provides a novel process for preparing 2b-heterocyclyl methyl penam derivatives of formula (I):n n n [Wherein R 1 represents a carboxylic acid protecting group such as hydrogen, ester, or a pharmaceutically acceptable salt; R 2 and R 3 may be the same or different and independently represent hydrogen, halogen, NH 2 , acylamino, phthalimido, provided that R 2 and R 3 are not simultaneously NH 2 , acylamino, phthalimido ; Het represents a 5 or 6 membered NH containing heterocycle ring system containing one or more heteroatoms selected from O, S or N],n n n The method of the present invention,n n n (i) A compound of Formula (VII), wherein L represents a leaving group, in the presence of a solvent and a base, at a temperature ranging from -10 to 110 ° C, wherein Reacting with a compound of formula (IX) to produce a compound of formula (IX);n n n (ii) oxidizing the compound of formula (IX) using a conventional oxidant in the presence of a solvent and an organic acid compatible with water to produce a compound of formula (I); And if necessary,n n n (iii) De-esterification of the compound of formula (I), wherein R 1 represents a carboxy protecting group, in the presence of a base and a solvent incompatible with water using a metal catalyst, thereby R 1 Obtaining a compound of formula (I) representing hydrogen. |
| priorityDate | 2002-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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