http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050021563-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2003-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20050021563-A |
| titleOfInvention | Novel Arylimidazole Derivatives, Preparation and Therapeutic Uses Thereof |
| abstract | The present invention relates to compounds of formula (I) Compounds of formula (I) can be used as NO synthetase inhibitors and sodium channel modulators (for the treatment of pain, multiple sclerosis, central or peripheral nervous system, etc.).n n n <Formula (I)>n n n n n n n n R 1 is H, alkyl, cycloalkyl or cycloalkylalkyl radical, R 2 is H or alkyl; R 3 is H, alkyl or aralkyl; X is a bond or a straight or branched chain alkylene radical (II); Y is H, cycloalkyl, OR 14 , SR 15 , NR 4 R 5 , or A is a bond or phenyl; B and B 'are independently selected from alkyl, NR 6 R 7 , SR 8 and optionally substituted carbocyclic aryl or 5- or 6-membered heterocyclic aryl radicals; R 4 is H, alkyl, aryl, cycloalkyl, cycloalkylalkyl, aralkyl, —C (O) R 9 , —C (O) OR 9 , —C (O) NHR 9 or —SO 2 R 9 radicals Or an aryl or aralkyl in which the aromatic ring is optionally substituted, R 5 is in particular H or alkyl, or R 4 and R 5 are optionally substituted 5- to 7-membered non-aromatic heteros with the nitrogen atom bonded thereto; To form a cycle; R 6 is (particularly) H or alkyl and R 7 is (particularly) H or alkyl; R 8 is an optionally substituted alkyl radical; R 9 is alkyl, haloalkyl, cycloalkyl or cycloalkylalkyl or is one of an optionally substituted aralkyl or aryl or heteroaryl radical; R 14 and R 15 are independently (particularly) alkyl, phenyl or aralkyl. |
| priorityDate | 2002-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 231.