| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd7c27b9ec61781656e6f039702fd568
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_143ac4fbe1e063c6a828a96cfffc34d5 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-12 |
| filingDate |
2003-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d51e662ed2aa02f7b04ebd60b707c02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_064289df355f2562af57f1bf85312b61 |
| publicationDate |
2005-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20050012432-A |
| titleOfInvention |
Preparation of an intermediate for the synthesis of atorvastatin |
| abstract |
The present invention relates to the preparation of (2R, of 4- (4-fluorophenyl) -2-isobutyryl-3-phenyl-4-oxo- N -phenyl-butyrylamide, which is a key intermediate for preparing atorvastatin (trade name: Lipitor). 3R) A method for the efficient preparation of isomers, wherein 4-methyl-3-oxo- N -phenylpentamide and 2-halo-1- (4-fluorophenyl) -2-phenone are nucleophilic in the presence of a weak base and a catalyst. According to the present invention, the intermediate for preparing atorvastatin can be obtained in high yield under mild conditions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7872154-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100613687-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8163959-B2 |
| priorityDate |
2003-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |