| abstract |
The present invention provides a pharmaceutical composition stably containing ghrelin or ghrelin derivative, which is an endogenous growth hormone secretagogue (GHS), against the growth hormone secretagogue receptor (GHS-R), and the pH of the aqueous solution in which ghrelin is dissolved. A pharmaceutical composition containing ghrelins, comprising an aqueous solution characterized by being in the range of 2 to 7, wherein the pH of the aqueous solution in which ghrelin is dissolved is in the range of 2 to 7 Pharmaceutical compositions, wherein the aqueous solution with a pH in the range of 2-7 is a buffer, in particular glycine hydrochloride buffer, acetic acid buffer, citric acid buffer, lactic acid buffer, phosphate buffer, citric acid-phosphate buffer, phosphoric acid-acetic acid-boric acid buffer or phthalic acid buffer It is a pharmaceutical composition whose concentration of ghrelin or ghrelin derivative in aqueous solution is 0.03 nmol / mL-6 micromol / mL. |