| abstract |
The present invention provides a pharmaceutical composition comprising (i) a renin inhibitor, (ii) a calcium channel blocker (CCB), and (iii) a diuretic, and a therapeutically effective amount of the pharmaceutical composition to a mammal in need thereof. Hypertension, heart failure, including (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiomyopathy, ventricular and ventricular arrhythmias, atrial fibrillation, atrial fluttering, and harmful vascular remodeling , Myocardial infarction and its sequelae, atherosclerosis, angina (either stable or unstable), renal failure (diabetic and non-diabetic), heart failure, angina, diabetes, secondary aldosteroneism, primary and secondary pulmonary hypertension, renal failure, for example For example diabetic nephropathy, glomerulonephritis (including IgA nephropathy), renal fibrosis, scleroderma, glomerulosclerosis, proteinuria of kidney disease, renal hypertension, and To treat a condition or disease selected from the group consisting of diabetic retinopathy, or to treat other vascular diseases such as migraine, peripheral vascular disease, Raynaud's disease, tubular hyperplasia, cognitive impairment (e.g., Alzheimer's disease), glaucoma and A method of managing a condition or disease selected from the group consisting of stroke, lung and liver fibrosis, fibrosis disease due to accumulation of excess extracellular matrix induced by TGF, and proliferative disease of smooth muscle cells, including uterine fibroids. |