http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20050007514-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fa0a8a718cac5315e779c640ffd410b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_319ac9d729dcf44fc0463b2d37d25e6b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10032 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-761 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00 |
| filingDate | 2003-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bced27a1d93849ea247d70643d08df63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13731a8ccab009be72d04032062b30d0 |
| publicationDate | 2005-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20050007514-A |
| titleOfInvention | Recombinant Adenovirus With Targeting Liver Cell and Pharmaceutical Composition Comprising The Same |
| abstract | The present invention relates to hepatocyte targeting recombinant adenovirus. The present invention provides a recombinant adenovirus and a liver disease therapeutic composition comprising the same by introducing an infection ligand of malaria spore body membrane protein having hepatocyte specific binding ability to adenovirus.n n n The recombinant adenovirus of the present invention can reduce the toxicity that can be caused in normal cells by inhibiting non-specific infection with cells of various organs other than hepatocytes. In addition, cancer cell-specific replicable hepatocyte-targeting recombinant adenovirus can be used to kill liver cancer cells, and therapeutic trans genes can be inserted into non-replicating hepatocyte-targeting adenovirus to treat liver diseases such as cirrhosis, hepatitis and malaria infection. Since it can be used, a smaller amount of virus may be safely and usefully used for gene therapy of liver cancer and hepatocytes. |
| priorityDate | 2003-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 326.