| abstract |
The invention relates to 5-[[2 (R)-[1 (R)-[3,5-bis (trifluoromethyl) phenyl] ethoxy] -3 (S)-(4-fluorophenyl) -4 -Morpholinyl] methyl] -1,2-dihydro-3H-1,2,4-triazol-3-one compound. The compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compounds are useful for the treatment of, for example, psychiatric diseases, inflammatory diseases and vomiting. |