abstract |
The present invention provides methods for the treatment of neurological and psychological disorders in mammals, including humans, comprising administration of selective PED10 inhibitors. In particular, the present invention relates to mood, motor and anxiety disorders; psychosis; Drugs such as alcoholism; Disorders with cognitive deficit symptoms; And the treatment of neurodegenerative disorders and diseases. Moreover, the present invention provides the use of papaverine as a selective inhibitor of PED10. The present invention also provides an assay method for identifying chemical compounds having activity as selective PDE10 inhibitors. |