http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20040104823-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_928ccd6a527fae43251ba8daf4ce9a68 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K- |
| filingDate | 2003-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34dcc752487f7e4987d9aacd00a3e982 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c23bf71593836caaa1a497e49069ff04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52f1ac04e1854874ea59178fef15d235 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_63b99b8efad43d90849bc86e32d858bd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b51c84733765f18df08d087b32cea83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d417f3ccf072405d842a2a5054d0c042 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a64a9d102719b5825e8231c59b77e8b6 |
| publicationDate | 2004-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20040104823-A |
| titleOfInvention | 4-[4-(4-Morpholino)anilino]pyrimidine derivatives, method for preparing thereof and antiviral pharmaceutical composition comprising the same |
| abstract | The present invention relates to a 4- [4- (4-morpholino) anilino] pyrimidine derivative useful as an antiviral agent. More particularly, the present invention has excellent antiproliferative effect of Hepatitis C virus (HCV). Novel 4- [4- (4-morpholino) anilino] pyrimidine derivatives represented by the following formula (1), pharmaceutically acceptable salts thereof, preparation methods thereof, and antiviral pharmaceuticals containing the compound as an active ingredient To a red composition. The novel 4- [4- (4-morpholino) anilino] pyrimidine derivatives represented by the general formula (1) according to the present invention are excellent in suppressing the proliferation of hepatitis C virus (HCV) and have low toxicity. Therefore, it can be usefully used as a prophylactic and therapeutic agent for hepatitis C.n n n [Formula 1]n n n n n n n n In Formula 1, R 1 represents a C 1 -C 4 straight or crushed alkoxy group, a -NR 2 R 3 group, or a 4- (R 4 ) -piperazin-1-yl group.n n n Further, in the substituent group representing the R 1, R 2 is hydrogen, or C 1 - a C 4 represents a straight or branched chain a group, R 3 is C 1 - straight or branched chain a group of C 4, C 1 - C 4 C 1 -C 4 linear or pulverized hydroxyalkyl group, C 1 -C 4 linear or pulverized alkyl group substituted with C 2 -C 6 linear or pulverized dialkylamino group, or C 1 -C 4 substituted with heterocyclic ring A straight chain or pulverized alkyl group of R 4 represents a straight chain or pulverized alkoxycarbonylmethyl group, a carboxymethyl group, or a —CH 2 —CO—NH—R 5 group of C 1 -C 4 .n n n And, in a substituent indicates the R 4, R 5 is C 1 - C 4 linear or grinding the alkyl group, C 1 - a straight or branched chain of C 4 hydroxy alkyl group, a C 3 - a C 6 cycloalkyl group, or a heteroaryl The cyclic ring represents a substituted C 1 -C 4 straight or crushed alkyl group. |
| priorityDate | 2003-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 195.