http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20040099441-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2003-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20040099441-A |
| titleOfInvention | Tricyclic thrombin receptor antagonists |
| abstract | The present invention relates to heterocyclic substituted tricyclics or pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions containing them, and diseases associated with thrombosis, atherosclerosis, restenosis, A method for treating hypertension, angina pectoris, arrhythmia, heart failure and cancer.n n n Formula In n n n n n n n In Formula I,n n n The dashed line represents any single bond;n n n (a) represents any double bond;n n n n is 0 to 2;n n n Q is cycloalkyl optionally substituted by R 13 and R 14 ;n n n Each R 13 is H, (C 1 -C 6 ) alkyl, (C 3 -C 8 ) cycloalkyl,-(CH 2 ) n6 NHC (O) OR 16b ,-(CH 1 ) n6 NHC (O) R 16b ,-(CH 2 ) n6 NHC (O) NR 4 R 5 ,-(CH 2 ) n6 NHSO 2 R 16 ,-(CH 2 ) n6 NHSO 2 NR 4 R 5 and- (CH 2 ) n6 C (O ) NR 28 R 29 where n 6 is 0 to 4, independently selected from haloalkyl, and halogen;n n n Each R 14 is H, (C 1 -C 6 ) alkyl, -OH, (C 1 -C 6 ) alkoxy, R 27 -aryl, (C 1 -C 6 ) alkyl, heteroaryl, heteroarylalkyl, hetero Cyclyl, heterocyclylalkyl,-(CH 2 ) n6 NHC (O) OR 16b ,-(CH 2 ) n6 NHC (O) R 16b ,-(CH 2 ) n6 NHC (O) NR 4 R 5 ,- (CH 2 ) n6 NHSO 2 R 16 ,-(CH 2 ) n6 NHSO 2 NR 4 R 5 and-(CH 2 ) n6 C (O) NR 28 R 29 , where n6 is 0 to 4, halogen, And haloalkyl independently;n n n R 13 and R 14 together form a 3-6 membered spirocyclic or heterospirocyclic ring wherein at least one R 13 or R 14 is- (CH 2 ) n6 NHC (O) OR 16b ,-( CH 2 ) n6 NHC (O) R 16b ,-(CH 2 ) n6 NHC (O) NR 4 R 5 ,-(CH 2 ) n6 NHSO 2 R 16 ,-(CH 2 ) n6 NHSO 2 NR 4 R 5 and -(CH 2 ) n 6 C (O) NR 28 R 29 wherein n 6 is 0 to 4;n n n Het is mono- or acyclic, optionally substituted with a heteroaryl group;n n n B is a bond, alkylene, or optionally substituted alkenylene or alkynylene;n n n The remaining substituents are as defined in the specification.n n n Combination therapy with other cardiovascular agents is also claimed. |
| priorityDate | 2002-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 164.