| abstract |
The present invention relates to the provision of novel aminomethyl substituted thiazolobenzimidazole derivatives of formula (I)n n n The derivative or salt thereof has a metabotropic glutamate receptor action, has excellent oral activity, and is useful as a medicament.n n n Formula In n n n n n n n In Formula I,n n n R 1 is an oxygen-containing saturated heterocyclic ring,n n n Alk 1 is lower alkylene,n n n m is O or 1,n n n Alk 2 is lower alkylene which may be substituted with an oxo group,n n n n is O or 1,n n n X is a bond, O, S or NR 5 ,n n n R 3 is H and the like,n n n R 2 , R 4 , R 5 , R 6 and R 7 are the same or different, H and the like,n n n Provided that when X is a bond and n is 1, R 3 is not lower alkyl or halogeno lower alkyl, m is 1, R 1 is OH or methoxy and Alk 1 is C 1-3 alkylene, 1) When X is a bond and n is 1 and R 3 is H or 2) when X is a bond and n is O and R 3 is cyclohexane, R 4 is a group other than methyl. |