| abstract |
The present invention relates to a method for treating a disease in response to the blocking of sodium ion channels using a novel aryl-substituted pyrimidine compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof.n n n Formula In n n n n n n n (Wherein A, R 1 , R 2 , R 3 , and R 4 are defined herein)n n n The present invention also provides for the treatment of neuronal damage following anterior cerebral ischemia and focal ischemia, treatment or prevention of neurodegenerative conditions such as atrophic lateral sclerosis (ALS), and anti tinnitus, anticonvulsants, antidepressants, local anesthetics and antiarrhythmics. The use of a compound of formula (I) usable for the treatment, prevention or alleviation of both acute or chronic pain as and the use of the compound of formula (I) for the treatment or prevention of diabetic neuropathy. |