| abstract |
Compounds of formula (I) are modulators of androgen receptors (AR) that act in a tissue selective manner. It is useful as an agonist of androgen receptors in bone and / or muscle tissue while antagonizing AR in the prostate of male patients or the uterus of female patients. Therefore, these compounds include osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, fractures, bone damage, osteopenia, weakness after bone reconstruction surgery, aging skin, hypogonadism, menopausal symptoms in women, atherosclerosis, hypercholesterolemia Caused by androgen deficiency, including hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint correction, HIV wasting syndrome, prostate cancer, cancerous fluid, muscular dystrophy, premature ovarian insufficiency, and autoimmune diseases Useful in the treatment of conditions that may be ameliorated by androgen administration, alone or in combination with other active agents. |