| abstract |
PKB (Akt) activator containing a compound represented by the following formula (I), a salt of the compound, or a prodrug thereof:n n n [Formula I]n n n n n n n n [Wherein, R 1 and R 2 each represent hydrogen, a hydrocarbon group or a heterocyclic group, or R 1 and R 2 together with adjacent carbon atoms form a ring;n n n R 3 represents hydrogen, a hydrocarbon group or a heterocyclic group;n n n W represents a group represented by the formula II, III or IV:n n n [Formula II]n n n n n n n n [Formula III]n n n orn n n [Formula IV]n n n n n n n n Wherein ring A represents an optionally substituted benzene ring; ring B represents an optionally substituted 5-7 membered nitrogen-containing heterocycle; R 4 is an aromatic group substituted aliphatic hydrocarbon which may have other substituent (s) Group or aromatic group-containing acyl R 5 represents hydrogen, C 1-6 alkyl, or acyl R 4c represents an aromatic group, aliphatic hydrocarbon group or acyl; X represents oxygen or sulfur);n n n Y represents oxygen, sulfur or NH;n n n Ring C represents an optionally substituted benzene ring.n n n In addition, the use of the activator in the prophylaxis / treatment or as a prophylactic / treatment for depressive psychosis, anxiety disorder, affective psychosis or PTSD. |