| abstract |
The compound of formula (I) and optionally a compound selected from isomers thereof, N-oxides and addition salts with pharmaceutically acceptable acids or bases, and pharmaceuticals containing the compound are 13-type matrix metalloproteases It is useful as a specific inhibitor of.n n n <Formula I>n n n n n n n n In the above formula,n n n X 1 , X 2 and X 3 represent a -CR 3 group as defined by N or R 3 in the specification, G 1 represents a group selected from the groups of formulas i / a and i / bn n n <Formula i / a>n n n n n n n n <Formula i / b>n n n n n n n n {Wherein R 4 , R 5 and R 6 are as defined in the specification}, G 2 is a carbon-carbon triple bond, -CH = C = CH-, C = O, C = S, S (O) n1 ( N1 represents an integer including 0 to 2) or a group selected from the group of formula (i / c)n n n <Formula i / c>n n n n n n n n {Wherein Y 1 represents O, S, -NH or -N alkyl, Y 2 represents O, S, -NH and -N alkyl}, n represents an integer including 0 to 6, m is 0 An integer comprising from 7 to 7, Z 1 represents -CR 9 R 10 (R 9 and R 10 as defined in the specification), A represents a ring system, R 1 is H, optionally substituted alkyl, Alkenyl, alkynyl and a group selected from the group of formula i / dn n n <Formula i / d>n n n n n n n n {Where p, Z 2 , B, q and G 3 are as defined in the specification} |