| abstract |
Described herein are compositions and methods for inhibiting articular cartilage degradation. The composition of the present invention preferably comprises a plurality of cartilage protective agents, including one or more agents that enhance cartilage anabolic activity and one or more agents that inhibit cartilage catabolic activity. The compositions of the present invention may also include one or more pain and inflammation inhibitory agents. The compositions of the present invention may be administered systemically to treat patients at risk of cartilage degradation in several joints and may be suitably formulated in a carrier or delivery vehicle targeted to the joint. Alternatively, the compositions of the present invention may be injected or injected directly into the joint. |