http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20040091101-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2003-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2004-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20040091101-A |
| titleOfInvention | Heterocyclic amide derivatives having glycogen phosphorylase inhibitory activity |
| abstract | The present invention provides heterocyclic amides of formula (1) or pharmaceutically acceptable salts or prodrugs thereof:n n n [Formula 1]n n n n n n n n In which Z is CH or nitrogen; R 4 and R 5 together are -SC (R 6 ) = C (R 7 )-or -C (R 7 ) = C (R 6 ) -S-; R 6 and R 7 are for example selected from hydrogen, halo, C 1-4 alkyl and C 1-4 alkanoyl; A is phenylene or heteroarylene; n is 0, 1 or 2; R 1 is selected from, for example, halo, nitro, cyano, hydroxy, carboxy; r is 1 or 2; Y is -NR 2 R 3 or -OR 3 ; R 2 and R 3 are selected from, for example, hydrogen, hydroxy, aryl, heterocyclyl and C 1-4 alkyl optionally substituted with one or two R 8 groups; R 4 is selected from, for example, hydrogen, halo, nitro, cyano, hydroxy, C 1-4 alkyl and C 1-4 alkanoyl; R 8 is, for example, hydroxy, -COCOOR 9 , -C (O) N (R 9 ) (R 10 ), -NHC (O) R 9 , (R 9 ) (R 10 ) N- and -COOR Selected from 9 ; R 9 and R 10 are for example selected from hydrogen, hydroxy, C 1-4 alkyl optionally substituted with one or two R 13 ; R 13 is selected from hydroxy, halo, trihalomethyl and C 1-4 alkoxy. This compound possesses glycogen phosphorylase inhibitory activity and is therefore useful for the treatment of disease states associated with increased glycogen phosphorylase activity. The present invention also discloses a method for preparing the heterocyclic amide derivative and the pharmaceutical composition containing the same. |
| priorityDate | 2002-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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