abstract |
The present invention provides a compound of formula (I) that is a chemokine (particularly CCR3) activity modulator (eg used in the treatment of asthma). The present invention also provides a process for preparing 4- (3,4-dichlorophenoxy) piperidine which is useful as an intermediate for preparing certain compounds of the present invention.n n n <Formula I>n n n n n n n n Wheren n n X is CH 2 , O, S (O) 2 or NR 10 ; Y is a bond, CH 2 , NR 35 , CH 2 NH, CH 2 NHC (O), CH (OH), CH (NHCOR 33 ), CH (NHSO 2 R 34 ), CH 2 O or CH 2 S; Z can be C (O), or if Y is a bond, Z can also be S (O) 2 ; R 1 is C 4-6 cycloalkyl fused to an optionally substituted aryl, optionally substituted heterocyclyl or benzene ring; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 , R 9 , R 10 , R 32 , R 33 , R 34 and R 35 are as defined herein. |