| abstract |
The present invention relates to the use of a compound of formula (I) and as a medicament for the treatment of a condition alleviated by antagonism of the 5-HT 2B receptor, in particularn n n n Formula In n n n n n n n n Wherein one of R 1 and R 4 consists of H, optionally substituted C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkyl-C 1-4 alkyl and phenyl-C 1-4 alkyl Selected from the group and the other of R 1 and R 4 is an optionally substituted C 9-14 aryl group; R 2 and R 3 are (i) independently H, R, R ', SO 2 R, C (= 0) R, (CH 2 ) n NR 5 R 6 (wherein n is 1-4, R is 5 and R 6 are independently selected from H and R, wherein R is optionally substituted C 1-4 alkyl and R ′ is optionally substituted phenyl-C 1-4 alkyl), or (ii) they are bonded And optionally substituted C 5-7 heterocyclic group. |