| abstract |
The present invention relates to a protein conjugate with a prolonged physiological activity duration, specifically, a physiologically active polypeptide, a non-peptidyl polymer and an immunoglobulin are covalently bound to each other, and the persistence of the physiologically active polypeptide is increased. Protein conjugates and their use. The protein conjugate of the present invention maintains relatively high in vivo activity of the physiologically active polypeptide, significantly prolongs its half-life in blood, and has a low risk of inducing an immune response, and thus can be used for the development of a sustained preparation of various polypeptide drugs. |