| abstract |
The present invention is a heterocyclic compound represented by the general formula (I) and having an elastase inhibitory activity; And intermediates for its synthesis:n n n n n n n n n n n n n In formula (I), in which R 1 is a heterocyclic group represented by formula (II), [wherein A represents the presence or absence of a benzene ring; X is oxygen atom, sulfur atom or NH, Y is nitrogen or CH], the heterocyclic group is a lower alkyl group, a lower alkoxy group, and a phenyl group which may be optionally substituted by lower alkyl, lower alkoxy or halogeno, optionally halogenated It may be substituted by the same or different substituents of 1 to 3 selected from the group consisting of, and R 2 and R 3 may be a hydrogen atom or hydroxyl, or both may form an oxo group together if not a hydrogen atom. . |