| abstract |
The present invention discloses isolated human monoclonal antibodies that bind to PSMA, and related antibody-based compositions and molecules. Such human antibodies can be produced in non-human transgenic animals, eg transgenic mice, capable of producing multiple isotypes of human monoclonal antibodies through V-D-J recombination and isotype conversion. Also disclosed are pharmaceutical compositions comprising said human antibodies, non-human transgenic animals and hybridomas producing said human antibodies, and methods of treatment and diagnosis using said human antibodies. |