| abstract |
An object of the present invention is to provide an antibody against fibroblast proliferation factor-23. The present invention includes a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 1 or an amino acid sequence in which one or several amino acids are deleted, substituted or added in the amino acid sequence shown in SEQ ID NO: 1, and having fibroblast growth factor-23 activity. An antibody obtained by immunizing a polypeptide with an animal and having phosphoric acid metabolism or vitamin D metabolic regulation activity is an antibody represented by the following (a), (b) or (c).n n n (a) an antibody recognizing the 180th to 194th or 237th to 251nd amino acid sequences shown in SEQ ID NO: 1n n n (b) Antibodies produced by hybridomas with accession numbers FERM BP-7838, FERM BP-7839, FERM BP-7840, or FERM BP-8268.n n n (c) an antibody produced by a hybridoma having an accession number of FERM BP-7838, FERM BP-7839, FERM BP-7840, or FERM BP-8268 in binding to a polypeptide comprising the amino acid sequence shown in SEQ ID NO: 1; Competing antibodies. |