| abstract |
A therapeutic agent for dry eye and diseases associated with dry eye, comprising as an active ingredient a peptide represented by formula (I) or a pharmaceutically acceptable salt thereof:n n n [Formula I]n n n H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-X 1 -Gln-X 2 -Ala-Val-X 3 -X 4 -Tyr- Leu-X 5 -X 6 n n n Wherein X 1 , X 3 and X 4 each represent Lys or Arg; X 2 represents Met, Leu or nLeu; X 5 represents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn -Ser-Ile-Leu or Asn-Ser-Ile-Leu-Asn-X 7 , wherein X 7 represents a chemical bond, Gly, etc .; X 6 represents -OH or -NH 2 . |