http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20040063435-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5ad8562c578b061df7a2c3aee9d0e24 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-027 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-468 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-491 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-14 |
| filingDate | 2003-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd2b9461b29db37b2ddf83ee8acc386b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_81b1f8b820fccf74703eac2f94c3c7b7 |
| publicationDate | 2004-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20040063435-A |
| titleOfInvention | Method for determination of atenolol in plasma and apparatus therefor |
| abstract | The present invention relates to a method for detecting atenolol in plasma based on high performance liquid chromatography, and a device thereof, wherein the method for detecting atenolol in plasma according to the present invention includes a protein removal column using phosphate buffer as a developing solvent. A protein removal step of removing the protein from the plasma by adding the same; A concentration pretreatment step of flowing triethylamine into the protein removal column including the plasma from which the protein has been removed to block the phosphate buffer used as the developing solvent in the protein removal step from entering the concentration column of the concentration step; And concentrating the plasma from which the protein has been removed through the above steps in a concentration column while flowing triethylamine as a developing solvent while the inflow of the phosphate buffer solution is blocked. In order to effectively measure the concentration of atenolol in plasma, the present invention allows the plasma to pass through a protein removal column and a concentration column in succession using column switching of high performance liquid chromatography. Concentration of the atenolol in the protein and plasma can be performed continuously, significantly reducing time and cost, and excellent sensitivity can be achieved by using different development solvents suitable for each step of plasma protein, concentration and analysis. Thus, by continuously monitoring the plasma concentration of atenolol administered in the treatment of angina and arrhythmia, it can be used as an indicator in determining the appropriate dose of atenolol, and can be used as an indicator in formulation development. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-100401058-C http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-100581019-B1 |
| priorityDate | 2003-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.