| abstract |
The invention provides one or more polynucleotides expressed in chondrocytes from the following developmental and disease stages: fetal, normal, mild, osteoarthritis, moderate osteoarthritis, significant osteoarthritis. The invention also relates to arrangements and compositions comprising any combination of such polynucleotide sequences. The invention also provides methods of using the inventive arrangements for diagnosing osteoarthritis. The invention also provides a method for identifying a therapeutic agent that alters the expression level of a polynucleotide of the invention or alters the assimilation level of chondrolite. |