| abstract |
Compounds of formula (I) are useful for the treatment of urological disorders. In compounds, R 1 = H, halogen, OH, alkyl, haloalkyl, alkoxy, haloalkoxy, NO 2 , nitro, phenyl, substituted phenyl, heterocycle, substituted heterocycle, NR 3 R 4 (R 3 and R One or more substituents selected from tetravalent H, alkyl, acyl or alkoxycarbonyl); One or two substituents selected from R 2 = H, alkyl; Y = CH 2 or a bond; Q = CO, CS or SO 2 ; A = each may be optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heterocyclic, alkylamino, dialkylamino, arylamino or arylalkylamino; n is 1 or 2; X = Structural Formula (a), Structural Formula (b) and -N (R 5 ) -CH 2- (R 5 = H, methyl, benzyl group; W = Bond, N, CH, CH 2 , C (CN) C ( Amino moiety selected from OH) or C (COCH 3 ) (when W is a nitrogen atom or a CH, C (CN) C (OH) or C (COCH 3 ) group, the ZB group is attached to the W ring atom) When X is (a) or (b), Z = a bond, O, S, CH 2 , CH 2 CH 2 , CO, CHOH, OCH 2 , NH, NHCO or NHCONHCH 2 , but X is -N (R 5 ) -CH 2 -group, Z represents a CH 2 CH 2 or CH 2 O group, or both Z and B represent a 2,3-dihydro-benzo [1,4] dioxin-2-yl group; And B is a monocyclic or bicyclic aryl group or a monocyclic or bicyclic heterocycle, each of which may be optionally substituted. |