| abstract |
At least heavy and light chain constant regions are converted to human-originated sites and inhibit the binding of integrins and osteopontin or fragments thereof that recognize RGD sequence sites, and integrins that recognize SVVYGLR sequence sites or corresponding sequence sites An anti-osteopontin antibody that inhibits binding of an osteopontin or a fragment thereof. The antibody is useful as a therapeutic agent for autoimmune diseases, therapeutic agents for rheumatoid arthritis or rheumatoid arthritis, and provides a method for treating autoimmune diseases, rheumatoid or rheumatoid arthritis. This osteopontin antibody is also useful for diagnostic drugs and diagnostic methods of rheumatoid. |