| abstract |
The present invention relates to amide compounds and pharmaceutical compositions containing them, and more particularly to novel amide compounds and pharmaceutical compositions containing them as antagonists for vanilloid receptors (VR).n n n Diseases associated with the activity of vanilloid receptors include pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathy, nerve damage, diabetic neuropathy, neurodegenerative diseases, neurological skin disease, stroke, bladder hypersensitivity , Respiratory abnormalities such as irritable bowel syndrome, asthma and chronic obstructive pulmonary disease, skin, eye and mucous membrane irritation, fever, gastric-duodenal ulcer, inflammatory bowel disease and inflammatory diseases. The present invention provides pharmaceutical compositions for the prevention and treatment of these diseases. |