| abstract |
The present invention provides granules for the preparation of improved rapid melting pharmaceutical oral dosage forms. In addition to one or more medicaments, the granules consist of at least two agents selected from the group consisting of superdisintegrants (crospovidone, croscarmellose sodium, sodium starch glycolate, low substituted hydroxypropyl cellulose and pregelatinized starch), dispersants , An excipient combination consisting of a dispensing agent and a binder, and may also include other conventional ingredients such as sweetening and flavoring agents. The granules of the invention are advantageous in that they are stable and can be prepared without the aid of a solvent and without the need for special circumstances or handling. Dosage forms prepared therefrom, in particular tablets, on conventional devices disintegrate in about 25 seconds in the mouth. |