| abstract |
The present invention is to provide a means useful for more efficient, long-lasting treatment or prevention for diseases such as brain disorders, neurodegenerative diseases and the like. The present invention provides an inhibitor that can inhibit the binding of HMG-I protein and presenilin-2 mRNA exon 5, a neuronal cell death inhibitor that can inhibit neuronal cell death, and a presenilin-2 mRNA exon 5 defective splicing variant. A pharmaceutical composition useful for the treatment or prevention of a disease resulting from the production of, a method for treating or preventing this disease, and a use of the inhibitor. |