| abstract |
According to the present invention, a hyaluronic acid derivative in which a glycol polymer is bonded to hyaluronic acid by an amide bond, that is, a glycol polymer having a free amine group introduced at one or both ends thereof is directly connected to hyaluronic acid by an amide bond, or It relates to a hyaluronic acid derivative bound to hyaluronic acid via a gas and a method for producing the same. Since the hyaluronic acid derivative of the present invention has excellent biocompatibility and very high viscoelasticity and a structure of amide bonds, gels, films, and seals are used for various purposes such as anti-adhesion gels, anti-wrinkle agents, cosmetic aids, inserts for treating arthritis, drug carriers Can be used. |