| abstract |
A method of enhancing progenitor and stem cell numbers using compounds that bind chemokine receptor CXCR4 in animal subjects is described. Preferred embodiments of these compounds are compounds of formula (1) or pharmaceutically acceptable salts thereof.n n n Formula 1n n n Z-Linker-Z 'n n n In the above formula,n n n Z is a cyclic polyamine containing 9 to 32 ring members wherein 2 to 8 of the ring are nitrogen atoms, the nitrogen atoms are separated from each other by at least 2 carbon atoms, and the heterocycle is optionally nitrogen May contain other additional heteroatoms and / or may be fused to additional ring systems; orn n n Z is a chemical formula Wherein A comprises a monocyclic or bicyclic fused ring system containing one or more N and B is H or an organic moiety of 1 to 20 atoms;n n n Z 'is embodied in the form defined in Z above or alternatively is the formula -N (R)-(CR 2 ) n -X [wherein each R is independently H or straight, branched or cyclic alkyl (1-6C) ), N is 1 or 2, and X is an aromatic ring including a heteroaromatic ring or is mercaptan;n n n A "linker" may include oxygen atoms contained in a bond, alkylene (1-6C), or aryl, fused aryl, alkylene chain, or may contain a keto group or a nitrogen or sulfur atom. |