abstract |
It is an object of the present invention to provide compounds and pharmaceutical compositions useful as PGI 2 receptor agonists. The present invention comprises a pharmaceutical composition comprising as an active ingredient a compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof:n n n n n n n n In the formula, R 1, R 2 are the same or different and may be substituted represents an aryl, Y represents a N, CH, etc., Z represents, N or CH, A is NH, NR 5, O, S or ethylene, etc., R 5 represents alkyl or the like, D represents alkylene or alkenylene, E represents phenylene or a single bond, G represents O, S or CH 2, etc., R 3 , R 4 is the same or different and represents hydrogen or alkyl and Q represents carboxy, alkoxycarbonyl, tetrazolyl, carbamoyl, N- (alkylsulfonyl) carbamoyl and the like. |