| abstract |
The present invention relates to a hydroxyformamidine compound represented by the following formula (1) or a pharmaceutically acceptable salt thereof.n n n <Formula 1>n n n n n n n n In the formula, R 1 is a substituted morpholino group, a substituted piperidino group, a piperazin-1-yl group, a substituted piperazin-1-yl group, a thiomorpholin-1-yl group, a perhydroazin-1-yl group, a perhydro An azocin-1-yl group, a tetrahydropyridin-1-yl group, a pyrroline-1-yl group, etc .; X represents a nitrogen atom or CR 5 , and R 2 to R 5 are the same or different and each represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkoxy group, a trifluoromethyl group or a halogen atom.n n n In addition, the present invention provides a drug that inhibits the production enzyme of 20-HETE involved in microvascular contraction / expansion, cell proliferation-inducing action, etc. in major organs such as kidney and cerebrovascular vessel. |