| abstract |
The present invention provides angiogenesis, vascular disease, inflammatory disease, intraocular angiogenesis disease, reproductive system disease, central nervous system disease and cancer markers; methods for detecting thereof; Diagnostic kits of diseases; And drugs for the treatment of diseases. KIAA1036 shows overexpression in ovarian cancer and rectal cancer and expression in umbilical vein endothelial cells, and has the effect of inhibiting DNA synthesis, cell migration and lumen formation in the cells. Because of this property, KIAA1036 is useful as a marker for angiogenesis, vascular disease, inflammatory disease, intraocular angiogenesis disease, reproductive system disease, central nervous system disease and cancer. KIAA1036 is also useful for screening agonists, antagonists, DNA synthesis inhibitors, cell migration inhibitors, angiogenesis inhibitors, and the like. Substances obtained by screening, KIAA1036 and antibodies thereof, are useful as therapeutic agents for the aforementioned diseases. |