| abstract |
Thienyl-, furyl- and pyrrolyl-sulfonamides, pharmaceutically acceptable salts of sulfonamides, formulations and sulfonamides of salts, and the formulations and sulfonamides used to modulate or alter the activity of the endothelin family of peptides. Provide a method. In particular, formulations of sodium salts of N- (isoxazolyl) thienylsulfonamide, N- (isoxazolyl) furylsulfonamide and N- (isoxazolyl) pyrrosulfonamide are provided. Provided are methods for preparing alkali metal salts of hydrophobic sulfonamides. The method comprises dissolving the free sulfonamide in an organic solvent in the presence of a saturated alkali metal salt solution and recovering the formed sulfonamide salt from the organic phase. |