| abstract |
The present invention relates to N-aroyl cyclic amine derivatives or pharmaceutically acceptable salts thereof and their use as orexin antagonists.n n n <Formula I>n n n n n n n n In the above formula:n n n Y represents a bond, oxygen, or a group (CH 2 ) n where n represents 1, 2 or 3,n n n m represents 1, 2, or 3;n n n p represents 0 or 1;n n n X is NR, wherein R is H or (C 1-4 ) alkyl;n n n Ar 1 is aryl or an optionally substituted mono or bicyclic heteroaryl group containing up to 3 heteroatoms selected from N, O and S;n n n Ar 2 is phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S, wherein the phenyl or heterocyclyl group is substituted with R 1 and any optional substituents Or; Or Ar 2 represents an optionally substituted bicyclic aromatic or bicyclic heteroaromatic group comprising up to 3 heteroatoms selected from N, O and S;n n n R 1 is hydrogen, optionally substituted (C 1-4 ) alkoxy, halo, cyano, optionally substituted (C 1-6 ) alkyl, optionally substituted phenyl, or 4 selected from N, O and S An optionally substituted 5 or 6 membered heterocyclyl group including the following heteroatoms;n n n P is not 1 when Ar 1 is aryl. |