| abstract |
The present invention relates to a controlled-release composition of felodipine containing felodipine, a saccharide-based surfactant and methacrylic acid copolymer, and a method for producing the same.n n n The composition according to the present invention was able to effectively increase the solubility of felodipine, and the preparation method according to the present invention dissolves the pelodipine, the saccharide-based surfactant and the methacrylic acid copolymer in an organic solvent, and then associate with an excipient and dry the solvent. Therefore, it is possible to effectively solve the problems such as the residual organic solvent, the difficulty of stirring due to the high viscosity at the end of drying and the content non-uniformity, which is a problem when the conventional solid dispersion is prepared and used. |