| abstract |
The present invention relates to a fumarylol derivative, a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition comprising the same. Specifically, the fumarylol derivative of the present invention represented by the following Chemical Formula 1 is an acylation reaction to fumarylol. It is prepared by performing a substitution reaction with an amine compound containing various functional groups and additionally an oxirane ring-opening reaction, and excellent antiangiogenic effect and low toxicity, anticancer agent, cancer metastasis inhibitor, rheumatoid arthritis treatment, psoriasis or diabetic retinopathy It can be usefully used as a therapeutic agent.n n n Formula 1n n n n n n n n (Wherein B, R 1 , X, and Y are as defined in the specification). |