| abstract |
The present invention is directed to 2- {2-methyl-4-[({4- Provided is a method for preparing methyl-2- [4- (trifluoromethyl) phenyl] -1,3-thiazol-5-yl} methyl) sulfanyl] phenoxy} acetic acid according to the following scheme.n n n n n n n n [Wherein, R 1 is an alkyl group having 1 to 4 carbon atoms, an alkyl or aralkylsilyl phenol protecting group, R 2 is a hydrogen atom and a methyl group, R 3 is a carboxylic acid protecting group having an alkyl group having 1 to 4 carbon atoms, X 1 Is a halogen atom, a hydrogen atom, X 2 is a halogen atom and a leaving group which is highly reactive to the electron affinity reaction, and M is lithium and magnesium ions.]n n n The present invention also provides the general formulas (III) and (VII), which are intermediates for the preparation of compound (X). |