| abstract |
The present invention relates to novel aminopiperidine derivatives, methods for their preparation, pharmaceutical compositions and the use of such compounds in medicaments. Specifically, the compounds of formula (I) below block the interaction of the chemokine receptor with the viral envelope protein gp120 on the cell surface to prevent human immunodeficiency virus (HIV) from entering the cell. As a result, the compounds of the present invention can be advantageously used as therapeutic agents for treating diseases mediated by human immunodeficiency virus (HIV), alone or in combination with other HIV virus replication inhibitors or in combination with pharmacological ameliorators. The compounds of formula (I) are disclosed.n n n Formula In n n n n n n n Wheren n n R 1 , R 2 , R 3 , X and A are as defined in the specification. |