| abstract |
Antiviral agents as well as the compounds of formula (I) or pharmaceutically acceptable salts or isomers thereof for treating HIV, solid organ transplant rejection, graft versus host disease, inflammatory disease, atopic dermatitis, asthma, allergy or multiple sclerosis Or combinations with anti-inflammatory agents and pharmaceutical compositions are described:n n n Formula In n n n n n n n In the above formula,n n n Q, X and Z are CH or N; R, R 4 to R 7 and R 13 are H or alkyl; R 1 is H, alkyl, fluoroalkyl, R 9 -arylalkyl, R 9 -heteroarylalkyl, alkyl-SO 2- , cycloalkyl-SO 2- , fluoroalkyl-SO 2- , R 9 -aryl- SO 2 -, R 9 - heteroaryl, -SO 2 -, N (R 22 ) (R 23) -SO 2 -, alkyl, -C (O) -, cycloalkyl, -C (O) -, fluoroalkyl -C (O)-, R 9 -aryl-C (O)-, -NH-alkyl-C (0)-or R 9 -aryl-NH-C (O)-; R 2 is H; R 3 is H, alkyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, R 9 - aryl, R 9 - arylalkyl, R 9 - heteroaryl, or R 9 -, and heteroaryl-alkyl, X and Z that is respectively CH , R 3 is alkoxy, R 9 -aryloxy, R 9 -heteroaryloxy, alkyl C (O) O-, alkylaminoC (O) O-, alkylC (O) NR 13- , alkylOC (O) NR 13 -or alkylaminoC (O) NR 13- ; Or R 2 and R 3 together are = O, = NOR 10 , = N-NR 11 R 12 or = CH-alkyl; R 8 is substituted phenyl, substituted heteroaryl, naphthyl, fluorenyl, diphenylmethyl, alpha-substituted benzyl or alpha-substituted heteroarylmethyl; R 9 to R 12 are as defined above. |