| abstract |
The present invention relates to selective MMP-13 inhibitors which are pyridine derivatives of formula (I) or a pharmaceutically acceptable salt thereof.n n n <Formula I>n n n n n n n n In the formula,n n n R 1 and R 2 are independently hydrogen, halo, hydroxy, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, NO 2 , NR 4 R 5 , CN or CF 3 ;n n n E is independently O or S;n n n A and B are independently OR 4 or NR 4 R 5 ;n n n R 4 and R 5 are independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, (CH 2 ) n aryl, (CH 2 ) n cycloalkyl, (CH 2 ) n heteroaryl, or R 4 and R 5 together with the nitrogen to which they are attached contain a carbon atom and optionally contain a heteroatom selected from O, S or NH and optionally substituted or unsubstituted 3 to 8 In a circular ring;n n n n is an integer of 0 to 6. |