| abstract |
The present invention relates to compounds of the formula (1.0.0) which are useful as inhibitors of PDE4 in the treatment of diseases regulated by activation and degranulation of eosinophils, especially asthma, chronic bronchitis and chronic obstructive pulmonary disease.n n n n n n n n In the formula,n n n j is 0 or 1, and when j is 0, n must be 2; k is 0 or 1; m is 0, 1 or 2; n is 1 or 2; W 1 is -O-, -S (= 0) t -where t is 0, 1 or 2 or -N (R 3 )-; W 2 is —O—CR A R B — or absent; Y is = C (R 1 a )-or-[N⇒ (O) k ]-, where k is 0 or 1; R A and R B are —H substituted with 0 to 3 substituents R 10 ; -F; -CF 3 ; - (C 1 -C 4) alkyl; -(C 3 -C 7 ) cycloalkyl; Phenyl; Or benzyl or form a spiro residue only when R A and R B are taken together but m is 1; R C and R D have the same meaning as R A and R B , except that one of them must be -H; R 1 and R 2 are -H, -F, -Cl, -CN, -NO 2 ,-(C 1 -C 4 ) alkyl,-(C 2 -C 4 ) alkynyl, fluorinated- (C 1 -C 3 ) alkyl, -OR 16 and -C (═O) NR 22 a R 22 b ; R 3 is H, — (C 1 -C 3 ) alkyl, phenyl, benzyl or —OR 16 ; R 4 , R 5 and R 6 together with other meanings Can form; Q 1 , Q 2 and Z are as defined herein. |