http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20030071731-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-002 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-645 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-59 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-16 |
| filingDate | 2003-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2003-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20030071731-A |
| titleOfInvention | Stereoselective microbial reduction of a racemic tetralone |
| abstract | The present invention is to perform a stereoselective microbial reduction by the microorganism of the following reaction formula 1, including the compound of formula (1) shown in Scheme 1, including an enzyme derived from the microorganism or an enzyme derived from the microorganism and a cofactor for the enzyme Contacting with an enzymatic reduction system; And incubating the resulting mixture to produce (4R) tetraralol of formula (2) and leaving (4S) tetraral or "chiral tetraralon" of formula (5) substantially unreacted. It relates to a method for performing stereoselective reduction of racemic tetralron by a microorganism according to Scheme 1, comprising:n n n n n n n n n n The chiral tetraralone can be used to synthesize sertraline. The method of the present invention also optionally comprises separating (4S) tetralon of Formula 5 from (4R) tetraralol of Formula 2. (4R) Tetralol can be recycled as a compound of Formula 1 and the process of the invention can be repeated to produce more of the desired (4S) Tetralon of Formula 5. |
| priorityDate | 1998-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 83.