| abstract |
The present invention also provides for the inhibition of AT 1 mediated effects, and bradykinin mediated effects, together with the maintenance of AT 2 receptor mediated effects of angiotensin II (ANG II), including co-administration of effective amounts of ANG II antagonists and ACE inhibitors. Methods of treating indications that may be positively affected by increasing ACE inhibition, eg, reducing the incidence of stroke, acute myocardial infarction or cardiovascular death, or increasing AT 1 receptors in the subepithelial region or AT 2 in the epithelium A method of treating indications associated with an increase in receptors, pharmaceutical compositions comprising ACE inhibitors with ANG II antagonists, and the use of ANG II antagonists and ACE inhibitors for the preparation of corresponding pharmaceutical compositions. |