| abstract |
The present invention relates to sulfonamide derivatives having a fatty affinity moiety and being substantially soluble. The sulfonamide derivatives are remarkably used as pharmaceutically active compounds. The invention also relates to pharmaceutical formulations containing such sulfonamide derivatives. The sulfonamide derivatives are effective regulators of the JNK pathway, which are particularly effective and selective inhibitors of JNK2 and 3. Moreover, the present invention relates to novel sulfonamide derivatives as well as methods for their preparation. Compounds of formula (I) according to the invention according to the invention which are suitable pharmaceutical preparations are those in which Ar 1 and Ar 2 are independently of each other an aryl or heteroaryl group, X is O or S, preferably O, and R 1 is hydrogen or C Is a 1- C 6 -alkyl group and R 1 forms a ring of 5-6 elements, substituted or unsubstituted with Ar 1 , n is an integer from 0 to 5, preferably 1-3 and most Preferably 1; Y in structural formula I is 4-12 elemental saturated cyclic or bicyclic alkyl containing a nitrogen atom, said nitrogen atom forming a bond with a sulfonyl group of structural formula I, and said 4-12 elemental saturated cyclic or bicyclic Alkyl is substituted with at least one ionizable moiety carrying a fatty affinity chain. |