| abstract |
The present invention provides compounds of formula (I), wherein R a , R 1 , R 2 , Y and R 3 have the definitions herein and pharmaceutically acceptable derivatives thereof (including prodrugs), which compounds and derivatives Is useful as a competitive inhibitor of trypsin-based serine proteases, such as thrombin, or as a prodrug of this inhibitor, and therefore is particularly useful in the treatment of conditions requiring inhibition of thrombin or as an anticoagulant. |